System Configuration : System Setup : Configuring Pro Tools Hardware Settings : Selecting an Audio Interface to Configure

Selecting an Audio Interface to Configure
The Peripherals list in the Hardware Setup lets you select any audio interface connected to your Pro Tools system associated with the selected Current Engine setting in the Playback Engine dialog.
To change the Current Engine setting to use a specific audio interface or DAE (such as HD TDM, 003, a third-party Core Audio or ASIO interface, or Pro Tools Aggregate I/O), see Current Engine).
For Avid HD audio interfaces (such as HD OMNI or HD I/O) you can configure the signal routing, digital I/O format, default sample rate, clock source, and other hardware-based settings for each HD peripheral connected to your system.
For Pro Tools audio interfaces (such as 003 or Mbox 2) you can configure the signal routing, digital I/O format, default sample rate, clock source, and other hardware-based settings depending on your system configuration
For third-generation Mbox family audio interfaces, M-Audio audio interfaces, and third-party Core Audio (Mac) and ASIO (Windows) compatible audio interfaces, use the Launch Setup App button to launch the control panel for configuring your specific audio interface.